CONTENTS

In order of relevance

Introduction

My Study
My Regimen
My Story
My Theory
My Advice
My Diagnosis
My Opinions

Mental Attitude
Self Healing

Frequently Asked Questions
Useful Links

Antioxidants
Antiox Articles

OPCs
Vitamins
Minerals & Aminos
Medications 

Diet
Liver Function
Healthy Foods 

Stress
Inspiration
Therapies
Treatments
Theories

Articles
Mycoplasma
Lyme Disease
Organophosphates

Talking to Doctors
Diagnosing ALS
Self Assessment

Acknowledgements

Steven Shackel

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MINERALS & AMINO ACIDS

(ALS) Amyotrophic Lateral Sclerosis or (MND) Motor Neurone Disease
are referred to as ALS/MND. PALS is short for People (or a person) with ALS.


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Please read the following before spending a great deal of money
and possibly even stressing your body by taking supplements
that superficially appear to be helpful.
The choice of supplements is far more complex...



Some minerals will directly affect the metabolisation of others and an increase in one will cause an imbalance or decrease in another. This sometimes works in only one direction. 

In the diagram below note that Cadmium (Cd) influences Copper (Cu) and Copper influences Iron (Fe) but the reverse is not true.  Excess Sodium (Na) may decrease Potassium (K) and vice verse. 

For a person with hypertension it may not be appropriate to increase Sodium (Na) even if it superficially appears to be beneficial in ALS/MND.  It may be better to decrease Potassium (K) thereby restoring sodium levels without taking potentially excessive amounts of sodium in food or as a supplement. Taken to an extreme, perhaps the balance of one mineral can only be restored by increasing or decreasing another mineral several steps removed from the apparent problem. Consider this before taking mineral supplements.





















Ca=Calcium Cd=Cadmium Co=Cobalt Cu=Copper Fe=Iron K=PotassiumMg=Magnesium Mn=Manganese Na=Sodium    P=Phosphorus    Zn=Zinc

Some vitamins, like minerals, cannot be properly metabolised if certain other vitamins or minerals are not present in sufficient quantities. 

Vitamin B3 is a good example: tryptophane requires Vitamins B1, B2, B6, Vitamin C, Magnesium, Zinc and Manganese to be converted to B3, so all these are important for that synthesis.  Taking a B3 supplement will not provide useful amounts of this vitamin unless the other vitamins and minerals exist in sufficient quantities to metabolise it.

Calcium is another example.  Taking a calcium supplement or eating calcium rich food does not mean that your body absorbs this nutrient. Interactions among nutrients can either help or hinder the absorption of other nutrients.  You are more likely to absorb calcium if you are also taking a vitamin D supplement.

Other supplements that aid absorption of calcium include, lactose (milk protein) lysine, potassium, sodium bicarbonate, vitamin B6 and vitamin A. Refined sugar can also assist in metabolising calcium but causes loss of calcium through urine! Some people can obtain more calcium from dairy products than from supplements and taking calcium supplements with food can increase their absorption by 10%.

Taking calcium in the evening is more effective than taking it in the morning. The calcium supplement calcium citrate is probably the most bioavailable of the calcium salts but can increase the undesirable absorption of aluminium! Dr Melvyn Werbach in his book "Foundations of Nutritional Medicine" explains numerous other ways in which simple calcium supplementation may fail or succeed according to the other foods and supplements taken in conjunction with calcium.

Based on my own research, I question the advisability of PALS taking calcium supplements unless they are extremely deficient in this mineral. Although calcium is essential for neuronal communication, simple calcium supplementation will not necessarily improve nerve conductivity and may even cause problems in some individuals.

Generally speaking, medications and supplements used in an attempt to slow the progress of ALS/MND are best taken in combination with complementary supplements at lower doses rather than taking excessively high doses of only one or two supplements.

Taking the "mega doses" sometimes suggested for supplements will, logically, tend to create an imbalance in other areas.  Taking large doses (5000mg) of plain vitamin E (alpha tocopherol) has been shown to deplete gamma tocopherol levels in the Central Nervous System (CNS). 

Taking a vitamin E "complex" (including alpha, beta, gamma and delta tocopherols) can help prevent this. (Christen S., et al., Gamma-tocopherol traps mutagenic electrophiles such as NOx and complements alpha-tocopherol: Physiological implications. Proc. Natl. Acad. Sci. USA, vol 94, pp. 3217-3222, Apr 1997.)


CHROMIUM Etienne-Emile Baulieu, French researcher at the College De France, has been giving elderly people low doses of synthetic DHEA as an anti-aging agent. The mineral chromium promotes an increase in this hormone.

An organic chromium supplement of 200 micrograms daily can help reduce accelerated ageing. (nb. oxidation of motor neurones is essentially a form of accelerated ageing).

The supplement should ideally be "biologically active" form of chromium, such as chromium nicotinate, for easier absorption and utilization by your body. If the chromium supplement is inorganic, your body must first convert it to an active form before it can be utilised.

The following is a partial description of B.C.100 Synergistic Chromium Compound made by Blackmore's, Australia:

Chromium is a trace element with a role in human biochemistry and physiology that is not well understood.  The focus of nutritional research regarding chromium is its role in carbohydrate and lipid metabolism. 

The deficiency of this mineral may contribute to the development of atherosclerosis.  Until recently, there were no accurate methods of Chromium determination.  Studies showed that elderly subjects dying from coronary artery disease had no Chromium in the aorta.  Rutolo D.A. & Hennessy G. Chromium-Take it to Heart lnt.Clin.Nut.Rev.19833(4)7.

A study on rabbits supplemented with Chromium decreased the aortic plaque as well as the cholesterol in the area. Healthy people supplemented with Chromium showed increased HDL-cholesterol ("good" cholesterol) levels, while their triglycerides and LDL-cholesterol levels decreased.

ACTIVE INGREDIENTS














  1. G.T.E YEAST is a yeast cultured with Chromium bound as the G.T.E. complex.

  2. CHROMIUM AMINO ACID CHELATE is bound to vegetable amino acids.

  3. BREWERS YEAST is a Chromium rich yeast.
    These three sources supply available forms of organic Chromium and aid efficient absorption.

Magnesium and Phosphate are required in all reactions involving energy production, such as synthesis of metabolically important compounds, absorption and transport of nutrients and any physical activity.

MANGANESE AMINO ACID CHELATE is a trace mineral that activates numerous enzymes.  Is a catalyst in the synthesis of fatty acids and cholesterol and plays a part in protein, carbohydrate and fat production and can help nourish the nerves and brain.

POTASSIUM PHOSPHATE: A correct balance of extracellular and intracellular potassium is necessary to maintain nerve cell resting membrane potential. Symptoms of imbalance include lethargy, lassitude, learning difficulties and depression. A fall in intracellular levels, causing membrane depolarisation, can result in irritability, insomnia, over-sensitivity and hyperactivity.  A fall in extracellular levels can cause membrane hyper-polarisation with consequent depression of nervous function, lack of reaction to stimuli and poor concentration.

VITAMIN B3 is a coenzyme assisting in the breakdown and utilisation of protein, fats and carbohydrates.  It improves circulation and reduces cholesterol levels in the blood. Kidneys are the major route of chromium excretion.

Tissue levels of chromium declines with age, except in the lung where levels increase, possibly due to environmental factors.  Tissue levels may also vary with geographical location.  Blood Chromium levels do not appear to reflect or to be in equilibrium with tissue levels because some organs may retain Chromium longer than blood plasma and serum Chromium can fluctuate because of the effect of glucose/insulin.

ABSORPTION AND CELLULAR UPTAKE: Chromium compounds (CrIII) are not as well absorbed as the chromate compounds (CrVI).  Chromium compounds are transported via blood protein (including transferrin) while chromates are transported via erythocytes.  The mechanisms of cellular and intestinal Chromium uptake are not well understood.

CHROMIUM BIOAVAILABILITY: Inorganic Chromium may be used therapeutically but organic forms of Chromium, e.g. GTF complexes, have higher biological activity.  This may partly explain some of the variance in the results of trials.  Phytate-rich diets possibly decrease Chromium absorption.  Chromium is required to metabolise sugar but sugar may increases the excretion of Chromium.  High dosage zinc supplementation possibly interfere with Chromium absorption.

Chromium can affect carbohydrate and lipid metabolism through its association with insulin.  Chromium is thought to potentiate the action of insulin by forming a link between insulin and the cell membrane.  High insulin levels may affect the quantity and type of triglycerides circulating.

Owing to its insulin-potentiating action, Chromium could be of use to people with aberrant carbohydrate metabolism.  People with a long-term history of refined carbohydrate intake, if showing gylcemic symptoms, may benefit from short-term supplementation trial. Trivalent Chromium (Cr III), for example GTF complexes, show little toxicity compared to the hexavalent forms of Chromium (Cr VI). 

Chromium toxicity is most likely to occur through occupational exposure, e.g. inhalation of Chromium fumes.

CHROMIUM FOOD SOURCES: Brewer's Yeast (but not Torula Yeast), whole grains, black pepper, molasses, oysters and rice bran.

DOSAGE (of Blackmore's B.C.100 Synergistic Chromium Compound): One tablet daily with main meal or as professionally prescribed.  Preferably taken separately to any zinc supplement.

See also DHEA.

MAGNESIUM is important for neuro-muscular function and the utilization of calcium in the body.


[Magnesium chloride in combination with coconut oil has been claimed to slow and even halt the progress of ALS/MND. There is a great deal of information online. Search: Coconut oil Magnesium and ALS].


Calcium cannot be absorbed properly without vitamin D but vitamin D is toxic in large amounts and should only be taken under medical supervision.  Vitamin D is almost completely lacking in food, apart from fish-liver oils (although margarine is usually supplemented with vitamin D). Please see Vitamin D Information.

Our chief source of vitamin D comes from sunlight on our bare skin producing a substance that changes into vitamin D within the body.  Some PALS find that Calcium/Magnesium supplementation worsens fasciculations and cramping.  Supplements of all types should only be taken in conjunction with a healthy diet and/or other supplements to facilitate their metabolisation.
See Possible Medications.
Link to Magnesium website.


Simply ingesting protein will not increase muscle bulk
or replace muscle lost due to denervation.

Exercise is required to metabolise protein in a way that builds muscle tissue. Too much protein can be as harmful as too little.  It can cause calcium to be flushed from the body in urine. The loss of calcium is greater with high protein foods rich in phosphorus, such as meat and eggs. 

According to Dr Julian Whitaker, a contributor to Prevention magazine, excess nitrogen and sulphur in the blood from a high protein diet creates an acid con-dition that leaches calcium from bone.  The combined effect that the body loses more calcium than it takes in, so using calcium supplements may not help when you are eating excess protein.  Osteoporosis, the gradual deterioration of the bones is rare in countries where the diet is low in protein - even when calcium intake is relatively low.

People wishing to lose weight sometimes adopt a high protein, low carbohydrate diet. Dietary protein alone will not maintain the protein tissues of your body.

Without carbohydrates the body cannot use the proteins that are ingested. Carbohydrates spare protein and increase protein utilization. Attempt to eat only unrefined carbohydrates.

"Magnesium supplementation does not delay disease onset or increase survival in a mouse model of familial ALS".

ZINC is the "repair mineral". It plays a role in many metabolic functions including the normal absorption and function of vitamins. Taking a zinc complex affects general metabolic, neurological and psychological function and has been shown to exert a broad neuroregulatory effect on signal transduction, neuronal activity and brain function.

Zinc functions by maintaining spatial and configurational relationships necessary for enzymatic action. In this role it helps to bind enzymes to substrates and may modify the molecular shape of enzymes by simultaneously combining with amino acids at different places on the protein, thus affecting secondary, tertiary and quaternary protein structure.

In addition to its function in enzymes, zinc participates in the metabolism of nucleic acids and the synthesis of proteins. Zinc may also have an important role in cell division and in the synthesis of DNA . The combination of zinc and vitamin C are important for liver function.

A "Zinc complex" tablet or capsule is the best way of supplementing dietary zinc intake. Zinc is both an antioxidant enzyme cofactor and a stabilizer of cell membranes. It is vital to endothelial integrity, and may also protect against the potent, pro-inflammatory platelet activating factor (PAF).
Substances that help metabolisation: Protein
Substances that hinder: Iron, Copper, Calcium.


AMINO ACIDS

Amino acids are crucial to our wellbeing, They are the building blocks of protein throughout the body, are used to make infection-fighting antibodies and help us resist damaging free radicals.

There are twenty different amino acids found in biological systems, including the human body. They serve a range of functions, and are best known as the components of protein - every protein is made up of a combination of amino acids, sometimes in chains that are thousands of amino acids in length.

Amino Acid supplementation was once widely used to treat ALS/MND but results were not as good as expected. The use of amino acids in combination with other supplements may assist to some extent but used alone they are apparently not the "cure" some practitioners claimed them to be.



A QUICK GUIDE

To Selected Amino Acids


Alpha-Ketoglutarate (AKG)
Alpha-Ketoglutaric acid is a derivative of glutaric acid. AKG, also referred to as oxo-glutarate, is an important biological compound and is the keto acid produced by the removal of an amine group from a molecule of glutamate during the Krebs cycle, a series of chemical reactions involved in aerobic respiration that occurs naturally. If this cycle slows down, fat loss is prohibited, as fatty acids cannot be fully degraded.

During the Krebs cycle, a series of chemical reactions take place in living cells and is involved in energy production. The Krebs cycle occurs in the mitochondria of cells. More mitochondria are found in cells that expend a significant amount of energy, like muscle cells. AKG acts as a transporter of creatine to bring more creatine into the targeted muscle cells.  AKG when administered orally, spares glutamine, thus increasing glutamine synthesis and availability. See the Deanna Protocol

Alanine
May help with prostate and cholesterol problems.
Dairy, beef, poultry, wheat, yogurt, avocado, eggs.

Arginine
Immunity and sexual function.
Although it performs many roles in the body, arginine stands out for two main reasons: it strengthens the immune system, and is believed to enhance sexual activity. It also supports liver health, helping the body to eliminate toxins.
Wheat, nuts, seeds, brown rice, soy, raisins, chocolate, carob, dairy & meat.

Asparagine & Aspartic Acid
These two closely related amino acids support nervous system balance.
Dairy, beef, poultry and eggs.

Carnitine
Helps promote lean muscle growth and metabolise fat.
Popular among dieters and athletes alike.
Your body makes carnitine from lysine and methionine, but it is also found in meat and dairy products.

Cysteine (see also  NAC on Antioxidant Page
Hair, skin and nails. Detoxifying and liver support.
Helpful for healthy hair and nails, and particularly for skin Elasticity & cysteine is I perhaps most useful as an aid to detoxifying. It supports the liver and helps the body to eliminate toxins. Cysteine is also a component of a crucial antioxidant compound, glutathione.
Poultry, wheat, broccoli, eggs, garlic, onions and red peppers. Can be synthesised in the body.

Glutamine
Supports energy production for the brain. Glutamine is converted by the body into gamma- aminobutyric acid (GABA), a key energy source for the brain. Thus, it is important for mental activity and fighting mental fatigue.

Glycine
May prevent muscle wastage and support prostate health.
Readily found in food and can be manufactured in the body.

Histidine
Can help build muscle tissue and has a role in reducing allergic reactions. It is also reported to improve sexual arousal and performance in men and supplementation may help in cases of rheumatoid arthritis.

Isoleucine
Boosts recovery from muscular fatigue after exercise.
Almonds, cashews, chicken, eggs, fish, lentils, liver, meat, seeds, soy, wheat, dairy foods.

Leucine
Assists healing and recovery and may help balance blood sugar levels.
Helps to break down fats, and may help balance cholesterol levels.
Eggs, fish, poultry, lentils, meat, seeds, soy, wheat, almonds, dairy, beans, brown rice.

Lysine
Perhaps the best-known and most popular of all amino acids in supplement form, lysine helps prevent cold sore outbreaks. It is best taken at the first tingling sensation that a cold sore brings.
Fish, eggs, dairy, some beans, beef, soy, potatoes, cheese, potatoes, milk and brewer's yeast.

Methionine
Helps the body fight herpes and cold sore outbreaks.
Fish, eggs, dairy, beans, beef, garlic, onion, lentils, soybeans, other seeds.

Ornithine
Muscle growth and immunity
Meat, fish, eggs and other protein foods. Ornithine can also be made in the body.

Phenylalanine & Alanine
Natural relief from pain, anxiety and stress.
Sometimes used as a natural painkiller, phenylalanine is also believed to relieve depression and support the activity of neurotransmitters, the signal-carriers in the brain. It can be converted in the body into tyrosine.
Dairy, almonds, avocados, lima beans, peanuts, seeds.

Tryptophan
A precursor for seratonin production, tryptophan offers powerful relief from depression.
Dairy, beef, poultry, barley, brown rice, fish, soybeans, peanuts.

Tyrosine
Relief from stress and anxiety; promotes alertness.
One of the most popular of all amino acids in supplement form, tyrosine helps the body resist environmental stress of all kinds, and has even been used to help military personnel endure extremes of and fatigue,
AImonds, avocados, bananas, beef, dairy, eggs, fish, lima beans, pumpkin seeds, sesame seeds, soy.

Valine
Growth and repair of muscle tissue.
Protein-rich foods such as dairy, eggs, and meat, as well as mushrooms and some nuts.

Some Amino facts:
D-, L-, and DL. Often, there is a prefix before the name of an amino acid - L-, D-, or DL-. This is because every amino acid has a symmetrical twin - the L- form is the left-handed version, and the D- form is its mirror image. In nature, almost all amino acids are in the L- form: living organisms tend to produce only one or the other. Generally, this means that the L- form is preferable because it's what our bodies are designed for.

One exception is phenylalanine, where the D- form is believed to be more effective for the relief of depression, chronic pain, and possibly even Parkinson's disease. For this reason, a mixture of L- and D-phenylalanine, DL-phenylalanine, is the supplement of choice.

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Alphabetical Contents List
| Introduction | Acknowledgements | Antioxidants |
|
Antioxidant Articles | Articles | Diagnosing ALS | Diet | F A Q |
| Healthy Foods | Inspiration | Liver Function | Lyme Disease |
|
Medications | Mental Attitude | Minerals & Aminos | My Advice |
|
Mycoplasma | My Diagnosis | My Opinion | My Regimen | My Story |
| My Study | My Theory | OPCs | Organophosphates | Self Assessment |
|
Self Healing | Stress | Talking to Doctors | Theories | Therapies |
|
Treatments | Steven Shackel | Useful Links | Vitamins |
|
Home Page |